Topic: Neuroligin-2

Immunoglobulin superfamily member 9b (IgSF9b) is a cell adhesion protein that has been linked to the etiology of several psychiatric disorders, including bipolar disorder and schizophrenia. Based on previous studies in neuronal cultures, IgSF9b was proposed to specifically regulate the structure and function of GABAergic synapses in the brain through an indirect interaction with the synaptic adhesion protein Neuroligin-2. To date, however, very little is known about the expression pattern of IgSF9b in the intact brain, and the synaptic localization of IgSF9b in different brain regions has neve

Neuroligin-2 (Nlgn2) is a postsynaptic adhesion protein that regulates the organization of GABAergic inhibitory synapses. NLGN2 gene variants have been linked to several psychiatric disorders, and deletion of Nlgn2 in mice results in a pronounced increase in innate anxiety-related avoidance behaviors. It is unknown, however, whether Nlgn2 also regulates other forms of defensive behaviors, and through which neuronal circuits these effects are mediated. Here, we therefore investigated the consequences of Nlgn2 deletion on the neuronal circuits that control associative fear learning in mice. We f