Topic: neuroLSD1

Numerous long non-coding RNAs (lncRNAs) play pivotal roles in nervous system development and the modulation of neuronal activity, making them crucial physiological players and potential vulnerability points for neuropsychiatric disorders. MALAT1 stands out as one such lncRNA, exerting control over splicing events by sequestering specific SR-family splicing factors in nuclear inactive compartments such as the nuclear speckles, thereby impeding their action on target transcripts. Notably, nSR100, a member of the SR-family, serves as a key splicing regulator, facilitating the generation of neuroL

The stress response serves as a protective mechanism to address daily challenges, yet it's crucial for it to cease when the threat subsides, as prolonged stress engagement links to higher vulnerability to neuropsychiatric disorders.Lysine Specific Demethylase 1 (LSD1) is an epigenetic enzyme participating in the CoREST/HDAC2 corepressor complex regulating neuronal plasticity-related gene transcription. In the mammalian brain, LSD1 activity is modulated by its neurospecific splicing isoform neuroLSD1, lacking co-repressive activity as long as the ability to recruit corepressor partners. Numerou