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Topic: neuromuscular junction

Seminar
1 seminar
ePoster
1 ePoster

In Biology and Neuroscience

Seminar · Neuroscience

Homeostatic Plasticity in Health and Disease

Graeme Davis · UCSF, Department of Biochemistry and Biophysics Director, Kavli Institute for Fundamental Neuroscience

Mon, Apr 4, 2022 · 05:00 UTC

Dr. Davis will present a summary regarding the identification and characterization of mechanisms of homeostatic plasticity as they relate to the control of synaptic transmission. He will then provide evidence of translation to the mammalian neuromuscular junction and central synapses, and provide tangible links to the etiology of neurological disease.

ePoster · Molecular Neuroscience

BDNF/TrkB signalling, in cooperation with muscarinic signalling, retrogradely regulates PKA pathway to phosphorylate SNAP-25 and Synapsin-1 at the NMJ

Aleksandra Polishchuk, Víctor Cilleros-Mañé, Marta Balanyà-Segura, Laia Just-Borràs, Carolina Silvera Simón, Marta Tomàs, Meryem Jami El Hirchi, Erica Hurtado, Josep Tomàs, María Angel Lanuza · FENS Forum 2024

PKA, influenced by retrograde signalling from muscle contraction, enhances neurotransmission at the neuromuscular junction (NMJ). This occurs through the phosphorylation of key molecules in synaptic vesicle exocytosis, SNAP-25 and Synapsin-1. The BDNF/TrkB pathway, augmented by muscle contraction, is a known regulator of retrograde control in ACh exocytosis at the NMJ. This modulation, including muscarinic receptors M1 and M2 (mAChRs) linked with both PKA and BDNF/TrkB signalling, has not been studied until now. Here, we investigate how synaptic activity and muscle contraction regulate PKA sub