Topic: neuronal architecture

The actin cytoskeleton is a key component for neuronal architecture and function. Along the axon, actin filaments assemble into distinct subcellular structures in the initial segment, along the distal shaft and within presynaptic boutons. Despite advances in the field of super-resolution microscopy, little is known about the presynaptic actin cytoskeleton, because of difficulties in visualizing it alongside the highly enriched postsynaptic compartment.Our objective is to map the presynaptic actin cytoskeleton scaffold and identify its nanostructures to further understand its functions. We have

Brain derived neurotrophic factor (BDNF) plays a crucial role in regulating synaptic plasticity and neuronal architecture through complex downstream signalling cascades mediated via receptor Tyrosine Kinase B (TrkB). Impaired BDNF/TrkB signalling has been associated with several neurological disorders. A treatment with Fingolimod has been shown in vitro and in vivo to promote BDNF synthesis and release and exert BDNF-dependent neuroprotection. Estrogens are a group of steroid sex hormones synthesised by neurons and astrocytes predominantly in females. In the hippocampus, estradiol plays a cruc