Neuronal cell types

Columbia’s NeuroTechnology Center brings together cellular, systems and computational neuroscientists to examine dendritic computation, cortical circuitry, neuronal cell types and emerging neurotechnologies. The programme connects synaptic physiology and dendritic integration with neuronal morphology, cortical microcircuits, transcriptomics and methods for studying the mammalian brain. Speakers are Peter Jonas, Gábor Tamás, Idan Segev, Henrike Planert, Lida Kanari and Jonathan Ting, with two panel discussions. The online symposium takes place on 10 December 2026, 11:00–16:00 EST (America/New_

…hundreds to thousands of distinct neuronal cell types. However, in computational neuroscience, we often stick our heads in the sand and ignore these details, instead basing theory on homogeneous populations of simple ‘point neurons'. The problem with this approach is that it's currently unknown what is lost with such simplifying assumptions. The simplification may be entirely

…However, the cellular architecture of the amygdala and how it has evolved remain elusive. Here, we generated single-nucleus RNA-sequencing data for more than 200,000 cells in the amygdala of humans, macaques,mice, and chickens. Abundant neuronal cell types from different amygdala subnuclei were identified in all datasets. Cross-species analysis revealed that inhibitory neurons and inhibitory neuron-enriched subnuclei of the amygdala were well-conserved i

…first generated a comprehensive single-cell RNA sequencing dataset of the telencephalon of adult zebrafish and mapped the diversity of neuronal cell types to anatomical brain areas. Gene expression data of G-protein coupled receptors were mined to embed individual cell types in neuromodulatory networks, allowing inference about which modu

…Single-cell transcriptomics can provide insights into behavior-associated cell state changes. Here we present a detailed cell-type taxonomy of the adult mouse amygdala during fear learning and memory consolidation. We perform single-cell RNA sequencing on naïve and fear-conditioned mice, identify 130 neuronal cell types and validate their spatial distributions

Glial cells show great diversity and differ in terms of their functional roles. Microglia, oligodendrocytes, and astrocytes interact with neurons and thus ensure the functionality of the neurons. However, little is known about how they interact with different neuronal cell types. We investigate glial and neuronal interactions in a connectomic dataset with a resolution that enables us to see synapses and subcellular structures. Our area X dataset, a singing-related basal ganglia nucleus, in the zebra finch contains thousands of neurons and a million synapses and different glial cell types: astr

…been used to classify neurons into cell types. Classification based on morphology has classically been done by either laborious expert analysis through visual inspection or by computing a set of predefined features that could be quantitatively measured. Both approaches are prone to bias and subjectivity. The classification of neurons by experts was shown to have a high variance, and becomes infeasible with larger datasets. Similarly, the definition of fixed morphological features for classification