Topic: neuronal cells

Variability is a universal feature among biological units such as neuronal cells as they enable a robust encoding of a high volume of information in neuronal circuits and prevent hypersynchronizations such as epileptic seizures. While most computational studies on electrophysiological variability in neuronal circuits were done with simplified neuron models, we focus on the variability of detailed biophysical models of neurons. Using measures of experimental variability, we leverage a Markov chain Monte Carlo method to generate populations of electrical models that can reproduce the variability

Primary cilia, also called "the cells antenna", are centriole based sensory cellular organelles, which are present on almost all mammalian cells and became important during the last decades. They realize a variety of functions, including maintaining neuroplasticity and the adaption to hypoxic conditions via a variety of signalling pathways, including the SHH-signalling, the MEK-ERK-signalling or the PDGFRa-signalling pathway. Based on these observations, the work pursued the goal to investigate the interplay of the hypoxia-inducible factor 1alpha and primary cilia in neuronal cells. The establ