ePoster · Gerontology
Understanding the altered brain metabolism and oxidative stress: Insights into metabolic syndrome and premature aging in a novel obese rodent model
Jitendra Kumar Sinha, Shampa Ghosh, Krishna Kumar Singh, Manchala Raghunath · FENS Forum 2024
The proportion of aged individuals in the general population is increasing, and non-communicable diseases like obesity are major contributors to mortality in older individuals. The WNIN/Ob obese rat exhibits a significantly reduced average lifespan of 15 months. Exploring molecular and biochemical characteristics of these rats can establish them as appropriate model for studying the neurobiology of aging and obesity.We investigated the growth characteristics and lifespan of WNIN/Obobese rats, examined neuronal-glial changes, levels of oxidative stress, antioxidant enzyme activity, and DNA dama