Topic: neuronal progenitors

Due to the complexity of the events in the tissue after the traumatic brain injury, adequate therapeutic protocols still need to be improved. A growing number of data suggests that hyperbaric oxygenation (HBO) can influence the activity of adult neural stem cells (NSCs). The aim of this study was to investigate the effects of sensorimotor cortex ablation (SCA) and HBO on processes of neurogenesis in the subventricular zone (SVZ), rostral migratory stream (RMS) and around the lesion site. The experiments were performed on adult male Wistar rats, ten weeks old. Animals were randomized into two g

The meninges are a protective and nutritious tissue that surrounds the central nervous system (CNS) and supports the brain. Recent data, including from our team, have revealed that the meninges contain a myriad of immune cells, such as meningeal macrophages (MM). Interestingly, the meninges penetrate the brain parenchyma and contact sub-structures such as the hippocampus, which is one of the main neurogenic niches. This strategic position of the meninges and thus MM raised the hypothesis that these cells could play a role in hippocampal neonatal neurogenesis. To address this question, we used

Infections of the CNS represent a significant predisposing factor for the manifestation of acute and chronic seizures. Epilepsy is associated with hippocampal sclerosis and neuronal degeneration; thus a regenerative approach could constitute a novel therapeutic option, involving the promotion of adult neurogenesis within the subgranular zone of the dentate gyrus (DG). Although experimental seizures induced by chemoconvulsants or electrical stimulation transiently enhance neurogenesis, the implications of encephalitis and virus-induced seizures remain inadequately elucidated. Accordingly, we em