Topic: neuronal recordings

Study whether metabolic interventions can recruit oligodendrocyte-lineage cells for repair in progressive multiple sclerosis. The Blouet and Káradóttir laboratories combine demyelination models, pharmacological interventions, neuronal recordings, imaging and single-nucleus transcriptomics in a two-year translational research project.

Sensory stimuli are often predictable consequences of one’s actions, and behavior exerts a correspondingly strong influence over sensory responses in the brain. Closed-loop experiments with the ability to control the sensory outcomes of specific animal behaviors have revealed that neural responses to self-generated sounds are suppressed in the auditory cortex, suggesting a role for prediction in local sensory processing. However, it is unclear whether this phenomenon derives from a precise movement-based prediction or how it affects the neural representation of incoming stimuli. We address the