Neuronal recordings

…Nicholas Bush then describes neuronal recordings and computational approaches to understanding the circuits that generate rhythmic breathing.

…observed from subcortical neurons recordings (Schneider and Woolley.2013, Rabinowitz et al .2013). Moreover, several studies claimed that the behavioural discrimination performance correlates with the auditory cortex neuronal responses. In previous experiments performed in anae

Social deficits play a role in numerous psychiatric, neurological and neurodevelopmental disorders. Relating complex behavior, such as social interaction, to brain activity remains one of the biggest goals and challenges in neuroscience. Availability of standardized behavioral tests that assess social preference is however, limited. Here, we present a novel behavioral set-up and paradigm that we developed to measure social behavior, the modified elevated gap interaction test (MEGIT). In this test, animals are placed on one of two elevated platforms separated by a gap, in which they can engage

Auditory perception relies on predicting the acoustic consequences of our actions. The auditory cortex (AC) responds differently to expected versus unexpected self-generated sounds. Yet it remains untested whether AC dynamically updates predictions about self-generated sounds in a context-dependent manner.We developed a naturalistic audio-visual-motor virtual reality (VR) system for head-fixed mice. Real-time locomotion tracking was performed to provide artificial footstep sounds that were yoked to a precise phase of the step cycle, creating an ethological and experimentally manipulable form o

Sensory stimuli are often predictable consequences of one’s actions, and behavior exerts a correspondingly strong influence over sensory responses in the brain. Closed-loop experiments with the ability to control the sensory outcomes of specific animal behaviors have revealed that neural responses to self-generated sounds are suppressed in the auditory cortex, suggesting a role for prediction in local sensory processing. However, it is unclear whether this phenomenon derives from a precise movement-based prediction or how it affects the neural representation of incoming stimuli. We address the