Topic: neuronal regeneration

A traumatic brain injury (TBI) is a severe form of neurotrauma resulting from the disruption of normal brain function due to external forces such as direct impact, rapid acceleration/deceleration or a penetrating object. TBIs have been attributed to long-term deficits including physical and cognitive changes, sensory effects, and social-emotional alterations. Current therapeutic options are limited to handling the acute trauma; however, drugs preventing nerve damage and promoting healing are not available. In recent years, the therapeutic use of bioactive peptides (small chains of amino acids,

microRNAs (miRNAs) are small non-coding RNAs (ncRNAs) of ~22 nucleotides that regulate gene expression in all biological processes in health and disease, including nerve injury-induced neuronal regeneration and neuropathic pain. Although miRNAs have been under investigation for their potential application as biomarkers or even in novel therapeutic approaches, the signaling pathways involved in their regulation as well as their biological role remains elusive. Mice were subjected to the spared nerve injury model for neuropathic pain and paired-miRNA::mRNA sequencing was performed on dorsal root