Neuronal responses

…Models derived from their responses to artificial stimuli often have a hard time to generalize and predict responses to natural scenes. However, models directly learned on the responses to natural scenes can be hard to interpret. To address this issue, we have recently developed an approach where we add small perturbations to natural scenes and measure how these perturbations change neuronal responses, to better understand the features extracted by sensory neurons. I will show se

Since the identification of concept cells nearly two decades ago [1], the semantic invariance of single neurons in the human medial temporal lobe has been extensively investigated [2, 3]. Such investigations typically consist of an initial screening to identify semantically-tuned neurons and a subsequent follow-up experiment which uses the identified stimulus-response pairings to address a particular question. While often examined in the service of other scientific investigations, the initial screenings have rarely been the sole focus of investigation [4]. Given the challenges endemic to human

…orientation precision's effects on neuronal responses. MC precision is governed by four parameters: the orientation, the spatial frequency (SF), Bθ and Bsf. We analyzed responses from 411 neurons in area 21a, seeking patterns in orientation precision pro

…Neuronal responses in the mouse inferior colliculus (IC) were recorded using Cambridge NeuroTech and Neuropixels probes. Neurons exhibited

…interwoven by cell-type specific responses after the initial injury. This progressive cascade is collectively termed the "secondary injury", and involves inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar with an astrocyte border. Here, we turn to single-cell technology to unravel the underlying cellular and molecular tapestry of SCI. We compiled a series of comprehensive single-cell atlases of the injured mou

…Since then, direction-selective responses have been observed in the retina of several species, including mice, indicating motion analysis begins at the earliest stage of the visual hierarchy. Yet little is known about how retinal direction selectivity contributes to motion processing in the visual cortex. In this talk, I will present our experimental efforts to narrow this gap in our knowledge. To this end, we used genetic

…across trials, as trial-by-trial neuronal noise will propagate through the motor system. The extent to which correlated activity affects behavior depends on the properties of its translation into movement. A major hurdle in studying the effect of neural correlations on behavior is the need to assume a model of the relationship between neural activity and behavior. We developed a novel method that estimates the contribution of correlations to behavior, with minimal assumptions. We applied this method to the frontal eye field