Topic: neuropeptide release

In the realm of memory, environmental lighting exerts significant influence, impacting various cognitive processes such as fear and object memory. Within this context, our laboratory has previously conducted research demonstrating that brief exposure to light adversely affects social recognition memory (SRM) in mice. Specifically, we found that light exposure hampers the activity of oxytocin neurons located in the supraoptic nucleus (SON) through a pathway involving M1 SON-projecting intrinsically photosensitive retinal ganglion cells (ipRGCs) and GABAergic neurons situated in the perinuclear

Interleukin 6 (IL-6), its receptor (IL-6R), with the IL-6 signal transducer gp130 (IL-6ST) are well known regulators of innate immunity but also affect neuron morphology and function. More recent evidence suggests that they also play a significant role in shaping microbiota composition and gut-barrier function (1). However, the exact pathways and mechanisms are still elusive. We therefore investigated the involvement of functional IL-6 signaling in the bilateral communication between primary afferent neurons and gut microbiota.Transgenic mice with a conditional depletion of gp130 in neurons ex