Topic: newborn neurons

Adult hippocampal neurogenesis (AHN) occurs in the subgranular zone (SGZ) of the dentate gyrus (DG) in mice and can be modulated by events such as hyperexcitability present in epilepsy. Evidence shows increased aberrant AHN in chronic severe epilepsy models; however, the impact of mild seizures remains to be explored. In this study, we administered intraperitoneally a low (5mg/kg) or a high dose (25 mg/kg) of kainic acid (KA) to Ascl1/Tom young mice (6-8 weeks) that allow us to target new neurons, to induce acute mild or acute severe seizures, respectively and evaluate differences in neurons b

Lifestyle factors exert a significant influence on the structure and function of the brain. These effects are particularly pronounced in the hippocampus, crucial for learning and memory, known for its plasticity and the existence of adult neurogenesis—the generation of new neurons in adulthood. While the enhancing effect of environmental stimulation on adult neurogenesis has been extensively studied, there has been a notable lack of attention to its impact on other cell types within the adult neurogenic niche, such as microglia.In this study, we investigated the effects of environmental stimul