Topic: nicotinic acetylcholine receptor

Olfactory dysfunction is a common aspect of normal aging. It is also an early symptom of Alzheimer’s disease (AD). The olfactory bulb, the first processing station of olfactory information in the brain, receives cholinergic basal forebrain input, as does the neocortex and hippocampus contributing cognition and memory, respectively. This study aimed to clarify (1) the role of cholinergic input to the olfactory bulb in adult and aged rats, (2) the relationship between olfaction and cognitive function in older adults.In both adult and aged rats, under anesthesia, unilateral olfactory nerve stimul

Prader-Willi syndrome (PWS) is a neurodevelopmental disorder, characterized by hyperphagia, developmental delay and cognitive deficits. The PWS genomic locus (15q11-q13) is maternally imprinted and the pathology arises when the paternal genome copy is deleted, with maternal uniparental disomy of chromosome 15 or imprinting defects. This genomic locus harbors different C/D box small nucleolar RNAs (SNORDs) that feature short transcripts usually involved in post-transcriptional modifications of rRNA. In particular, SNORD116 is included in the majority of the disease-causing chromosomal deletions