Topic: nitric oxide synthase

It was previously reported that the nitric oxide synthase (NOS) inhibitor agmatine had anxiolytic and antidepressant-like effects in rodents (Aglawe et al Brain Res Bull 167:37, 2021). Since serotonergic (5-HT) neurons of the dorsal raphe nucleus (DRN), expressing NOS, had lower excitability than the non-NOS expressing ones (Gartside et al Eur J Neurosci 51:1881, 2020), the anxiolytic and antidepressant-like effects of agmatine might involve stimulation of 5-HT neurons of the DRN. The present study aimed to examine this hypothesis. Acute and chronic effects of agmatine were tested. In acute ex

Glioblastoma, a highly aggressive brain tumor, poses a formidable challenge due to factors such as angiogenesis, diverse mutations, and evasion of apoptosis. Nitric oxide (NO) plays multifaceted roles in physiological processes, including vasodilation, blood pressure regulation, neurotransmission, and immune response. In the context of glioblastoma, understanding the interaction between NO and tumor cells is crucial. Our study utilizes human and mouse glioblastoma stem cells to investigate how NO influences cell proliferation.We modulate NO activity by either enhancing (using SNAP) or inhibiti