Topic: NMDA

Information processing and communication in neuronal circuits is enabled by networks of dynamic inter-areal coupling of neuronal oscillations. These networks exhibit frequency-specific spatial and topological patterns and rely on hubs that are crucial for information routing. Oscillations are generated by fast synaptic neurotransmission among pyramidal cells and interneurons, and are subject to neuromodulation on slower timescales in a frequency- and region-specific manner. Efferent connections, receptor densities, and neurotransmitter reuptake regulation of neuromodulatory systems are highly

Astrocytes exhibit dynamic behavior in multiple sclerosis (MS), assuming both pro-inflammatory and anti-inflammatory phenotypes, yet their precise role in modelling the neuroinflammatory response in MS remains elusive. While mice are commonly employed for MS research, murine astrocytes fail to fully replicate the structural and functional complexity of their human counterparts, limiting the translation of findings from in vitro studies to the human context. Leveraging the unique characteristics of patient-derived iPSC astrocytes, this study aims to establish a platform for in vitro exploration