Topic: NMDA receptor blockade

Depression affects 30 million people worldwide, and women are diagnosed with this condition nearly twice as often as men. Cognitive impairments that develop during depression contribute to poor therapeutic outcomes and reduced quality of life. Recognizing the significance of sex as a variable in depression research, we investigated the procognitive properties of a multimodal compound- HBK-15 in female mice using two models of cognitive impairments: induced by NMDA receptor blockade or stress. We employed the object recognition test to assess intermediate recognition memory. We used MK-801 (NMD

Depression is a serious mental illness that includes both behavioral symptoms and cognitive dysfunction. With the growing problem of ineffective treatment, there is a constant need for compounds with rapid antidepressant and procognitive effects. A compound that has shown antidepressant-like activity after single administration in animal models is NLX-101. NLX-101 preferentially activates postsynaptic 5-HT1A heteroreceptors in the prefrontal cortex, stimulating extracellular signal-regulated kinase (ERK1/2) phosphorylation. Thus, this study aimed to evaluate the potential ability of NLX-101 to