Topic: nociceptive behaviors

Major depressive disorder (MDD) is a global health concern, displaying a diverse range of symptoms and a recognized association with chronic pain. Current evidence suggests that astrocytes play a key role in both disorders. Consequently, we investigated the effect of olfactory bulbectomy (OBX), a well-known model of depression-related behavior, on nociceptive behaviors and the number and morphology of astrocytes within the basolateral amygdala (BLA) in male rats. We conducted behavioral test, including the von Frey assessment of mechanical allodynia and acetone test of thermal cold allodynia,