Topic: Nogo-A

Learning and memory processes activate a specific ensemble of neurons distributed across different brain regions, the so-called engram, inducing in them lasting physical and chemical changes. The allocation of neurons to the engram depends on their relative excitability. Therefore, mechanisms regulating the balance between excitation (E) and inhibition (I) in the brain influence memory formation. Nogo-A negatively regulates neuronal plasticity and influences the E/I balance by promoting inhibitory, while suppressing excitatory synaptic transmission. Moreover, loss of function for Nogo-A result

The neuronal engram created during fear learning relies on both, plasticity of the neuronal network for its formation and the stability for persistence. The allocation of neurons to a specific engram depends on their excitability. Molecules regulating the excitation / inhibition balance (E/I balance) in the brain are therefore considered key players in engram formation. Nogo-A has been shown to influence the E/I balance, restrict activity-dependent functional and structural plasticity and modulate learning and memory formation. However, whether Nogo-A controls the memory engram formation and t