Topic: non-AcD cells

Recent data show that a significant fraction of cortical pyramidal neurons has an axon originating from a basal dendrite (axon-carrying dendrite, AcD) rather than from the soma. In the rodent hippocampus, these AcD cells convey privileged synaptic excitation especially in network states with strong perisomatic inhibition (Hodapp et al., 2022). We have recently shown that hippocampal AcD cells receive stronger commissural input than neurons with somatic axon origin (non-AcD) (Stevens et al., 2023).AcD cells are also present in the neocortex, though seemingly less frequent than in the hippocampu

Cortical principal neurons receive multiple synaptic inputs via their dendrites, integrate them in their soma and once a threshold is reached, generate action potentials. Dendritic branches express multiple mechanisms for modulation and integration of signals, depending on the spatiotemporal pattern of arriving inputs. Recently, we have reported a new structural feature of pyramidal neurons affecting neuronal signal processing: axon localization. In about 50% of CA1 hippocampal pyramidal cells, the axon emerges from a basal dendrite instead of the soma. Input to the axon-carrying dendrite (AcD