ePoster · Neuroscience
Investigating the acute impact of sweeteners sucralose and Ace-K on ATP production and mitochondrial respiration in the hypothalamic GT1-7 cell line challenged with increased glucose
Joulia Haydar, Claire Fenech, Fabienne Lienard, Basma Abed, Marie-annick Maire, Guillaume Walther, Loic Briand, Corinne Leloup · FENS Forum 2024
Aims. Acute consumption of sweeteners has become increasingly common in modern diets. However, emerging research suggests that the impact of sweeteners on the hypothalamus, involved in regulating food intake [CA1] and metabolism, may be deleterious. Several studies have raised concerns about their potential effects on brain cellular metabolism (Kohno D et al.,2016), suggesting a mismatch between detection of false sugar and the energy value actually detected. This study aimed to investigate the dose-dependent impact of sweeteners on these energetic processes. Methods. Using the hypothalamic ce