Decoding activity patterns across pyramidal cell dendritic trees during spontaneous behaviors using 3D arboreal scanning
Antoine Valera, Thomas J. Younts, Victoria A. Griffiths, Diccon Coyle, R. Angus Silver · FENS Forum 2024
Our understanding of how sensorimotor information is integrated across dendritic trees is limited by our ability to image these distributed 3D structures in awake animals. We overcome the existing limitations of rapidly measuring 3D dendritic activity and avoiding signal distortion by brain motion artefacts by utilizing our novel nonlinear 3D acousto-optic lens two-photon microscope with real-time 3D brain motion correction and innovative Ca2+ imaging analysis pipelines. This enable the study of sensorimotor information representation in dendritic activity patterns of awake mice during natural
ePoster · Neuroscience