Topic: nonnegative matrix factorization

In recent years, many calcium and voltage imaging methods have been developed in pursuit of a central goal of systems neuroscience: to study the function of large populations of neurons. Projective imaging methods, such as Bessel imaging, are a promising class of approaches in pursuit of this goal. These methods simultaneously record neural activity at a wide range of depths in the brain, effectively allowing scientists to image a volume of brain tissue. However, this added capability comes with a trade-off: all observed signals from the volume are projected onto a 2D imaging plane. Therefore,

Previous studies of cat and human locomotion have suggested that the nervous system organizes activities of multiple muscles in five muscle groups (muscle synergies) receiving synergy-specific time-dependent inputs. Two synergies contain flexor muscles and two-joint hamstrings and are active during the swing phase and swing-stance transition; the remaining three synergies consist of extensor muscles and two-joint thigh muscles and are active during the stance phase and stance-swing transition. Given a possible locomotor CPG organization, we hypothesized that split-belt locomotion with faster b