Topic: NOP receptor

ePoster: 2 ePosters

Implications of NOP receptor system in social impairments associated with migraine pain

Akanksha Mudgal, Olga Wronikowska Denysiuk, Darian Peters, Isabel Snow, Madeline Martinez, Lawrence Toll, Akihiko Ozawa, Katarzyna Targowska-Duda · FENS Forum 2024

Migraine, a neurological disorder characterized by recurring, intense headaches, disproportionately affects a significant portion of the population, particularly females. While its precise etiology remains elusive, it is thought to have arisen from a combination of genetic predisposition and environmental factors. This research endeavors to explore the neurobiological underpinnings of both the sensory and emotional aspects of migraine pain, as well as the associated social impairments. Using the nitroglycerin (NTG) migraine model, which induces vasodilation via systemic administration, we simu

ePoster · Neuroscience

Phenotypic characterization of nociceptin/orphanin FQ receptor knockout mice (NOP(-/-)) in different in vivo models of migraine and evaluation of the NOP receptor as a treatment target

Chiara Sturaro, Alessia Frezza, Pietro Pola, Michela Argentieri, Nurulain Zaveri, Girolamo Calò, Chiara Ruzza · FENS Forum 2024

Migraine is a pain disorder that affects 10 – 15% of the population worldwide. Even though there is a wide choice of therapeutics that includes different classes of well-tolerated drugs, numerous patients are still not satisfied with their treatment. Trigeminal ganglion and nucleus caudalis are enriched with nociceptin/orphanin FQ (N/OFQ) receptor (NOP)-expressing cells. The general aim of the present study is to investigate the role of the N/OFQ – NOP system in the modulation of migraine. This study evaluated the phenotype of mice with genetically induced knockout of the NOP receptor gene (NO

ePoster · Neuroscience