Topic: noradrenergic signaling

Nascent animals are most in need of learning to identify predators due to their vulnerability, yet paradoxically, are generally assumed not to be capable of such rapid, complex learning tasks. Here, a robotic fish-attacker interaction assay showed that larval zebrafish just a week of age learn to identify and avoid a robot following brief minutes-long periods of chase. Whole-brain calcium imaging identified noradrenergic signaling, consistent with a reinforcement signal, that was coupled to activity in populations spread across the larval pallium, subpallium, and habenula. Finally, targeted ne

Understanding the dynamic interplay between neuromodulatory systems and neuronal circuit dynamics is crucial for deciphering the underpinnings of complex behaviors. Noradrenergic signaling is widespread throughout the body and the brain and plays a pivotal role in the implementation of physiological processes and brain network configuration across arousal states. Yet, unraveling the causal relationship between norepinephrine release and concomitant neuronal dynamics poses a formidable challenge due to the intrinsic coupling of noradrenergic activity with behavioral changes.To resolve this conu