Topic: noradrenergic system

Age-related decline in brain glucose utilization might stem from noradrenergic system dysfunction, which governs brain metabolism and could play a role in age-related cognitive decline. Noradrenaline released from these neurons triggers intracellular Ca2+ and cAMP signals in astrocytes, facilitating glucose uptake, glycogen degradation, and aerobic glycolysis, producing lactate as an end-product. During heightened brain activity, lactate is transferred from astrocytes to neurons to serve as fuel. The extent to which noradrenergic regulation of brain cell metabolism is impaired in aged brains a

Deep brain stimulation (DBS) targeting the medial forebrain bundle (MFB) is emerging as a promising intervention for treatment-resistant depression. Our study systematically investigated the NA system in a depression model and explored the modulatory effects of mfb-DBS on this system.Using Flinders Sensitive Line (FSL) rats as a depression model and Sprague Dawley (SD) rats as controls, we examined the spatial distribution and myelination of NA fibers within the mfb under confocal microscopy, monitored real-time in vivo NA release in response to mfb-DBS in the mPFC and NAC during 6 different s