Topic: Novel Object Location test

The onset of Alzheimer disease (AD) and of abnormal sleep patterns are both signaled by initially minute but ultimately disastrous physiological malfunctions of the brain. Among these, the Locus Coeruleus (LC) belongs to the primary brain areas that show such malfunctions in the early stages of AD. The LC generates large noradrenaline (NA) signals that are key for the architecture of sleep in mice. In contrast, how LC malfunctions relate to sleep disturbances in AD remains unknown.We explore the real-time functionality of the noradrenergic system during AD’s prodromal phase in an established A

Ischemic stroke (IS) and Alzheimer's disease (AD) are debilitating neurological disorders marked by functional and cognitive deficits, sharing underlying pathological mechanisms. Recent research highlights the involvement of neurogenesis in both conditions, with alterations in neurogenesis linked to cognitive dysfunction. In our study, we aimed to investigate cognitive decline in a combined IS/AD model. To this end, IS was induced by permanent middle cerebral artery occlusion (pMCAO) in 4-months-old male and female 3xTg-AD vs wild-type (WT) mice. Our results revealed comparable sensorimotor re