Topic: NR1

Anti-NMDA receptor (NMDAR) encephalitis is associated with the presence of autoantibodies against subunit 1 of the NMDA receptor (NR1) resulting in a variety of psychiatric symptoms as well as cognitive and motor impairments. These autoantibodies can arise in adulthood but also during pregnancy where they have been shown to affect the developing foetal brain and are implicated in neurodevelopmental disorders including autism and learning disabilities. Binding of these autoantibodies causes internalization of surface NMDAR leading to their reduced expression and disrupted signalling. To what ex

Pheromone signalling regulates rodents’ social and reproductive behaviours. Learning and memorizing pheromone locations is a multimodal phenomenon since pheromones can be found on naturally occurring entities of various shapes and sizes in the environment. To investigate the neural basis of this behaviour, a pheromone place preference paradigm was developed, which required mice to use their olfactory and whisker systems to detect and memorize the pheromone locations. Female mice were trained to detect and learn the location of urinary volatiles from a chamber guarded by specific orifice sizes