Topic: Object-location Memory

The electrophysiological mechanisms of human memory encoding and recall are incompletely understood. Precise interaction of single-neuron activity and brain oscillations presumably play a critical role in this process. Here, we used human single-neuron recordings from an object-location memory task with separate periods for encoding and retrieval to analyze the timing of single-neuron activity in the medial temporal lobe relative to the local theta rhythm. 18 epilepsy patients participated in the task and contributed to 27 experimental sessions. We extracted single-neuron action potentials fro

The ability to recall the spatial location of objects is crucial for our everyday life. Such memory capability relies on the intricate communication between the hippocampus (HIP) and the medial prefrontal cortex (mPFC), and its decline is often observed with aging. Despite progress in understanding the role of HIP-mPFC communication in object memory, approaches to enhance its functionality are very limited. Therefore, we aimed to explore how optogenetic activation (priming) of the HIP-mPFC pathway can facilitate object-location memory in adult and aging mice. For this purpose, we injected mice