Topic: object place recognition

Brain rhythms of sleep influence sleep-associated memory consolidation. The modulation of sleep rhythms, such as the sleep slow oscillation (SO), can be used to investigate neurophysiological mechanisms of memory consolidation and the impact of sleep. Previously, closed-loop acoustic stimulation (CLAS) in humans during the SO Up-state successfully enhanced the slow oscillation rhythm and phase dependent spindle activity, although effects on memory retention have varied. Closely comparative studies in rodents that also monitor hippocampal activity are rare [1, 2]. Yet, a recent iEEG study [3] a

Memory formation requires translation, which is dependent mammalian target of rapamycin (mTOR) signaling. While it was shown that five hours of acute sleep deprivation attenuates mTOR-mediated translation in the hippocampus of male mice. Interestingly, we found that mTOR activity was also significantly reduced in the cerebellum of acutely sleep deprived male mice. A chronic sleep restriction of 20 hours of REM sleep loss per day for seven days also significantly reduced mTOR activity in the hippocampus and cerebellum of male mice. In female mice, five hours of acute sleep deprivation only sign