Topic: Object Recognition Test

Aggregation of amyloid-beta (Aβ) is among the earliest pathological changes in Alzheimer's disease (AD, Kamenetz et al., 2003). In some individuals, however, memory and other cognitive functions remain intact, despite the presence of abundant Aβ pathology (Stern, 2012). This suggests that neurons and networks can recruit mechanisms that protect against Aβ pathology, a concept known as cognitive resilience (CR). Notably, this occurs in a sex-dependent manner, with greater CR in females (Buckley et al., 2019, Ossenkoppele et al., 2020).The underlying mechanisms of resilience to AD pathology rema

The process of memory consolidation involves the transfer of information from short-term memory (STM) to long-term memory (LTM). Memory consolidation requires activation of the dorsal hippocampus (dHP), especially under conditions of high memory load. In this study, we asked whether there is a limit to the memory capacity, that is, the amount of information that can be stored during unique experiences. Using male and female outbred CD1 mice subjected to a modified version of the object recognition test, we found that females, despite having the same 6- object STM capacity as males, appear to t