Topic: odorants

Organisms continually tune their perceptual systems to the features they encounter in their environment. We have studied how this experience reorganizes the synaptic connectivity of neurons in the olfactory (piriform) cortex of the mouse. We developed an approach to measure synaptic connectivity in vivo, training a deep convolutional network to reliably identify monosynaptic connections from the spike-time cross-correlograms of 4.4 million single-unit pairs. This revealed that excitatory piriform neurons that respond similarly to each other are more likely to be connected. We asked whether thi

The mammalian olfactory system shows an exceptional ability for rapid and accurate decoding of both the identity and concentration of odorants. In a given scene, only a handful out of millions of possible odorants are present. Yet, the mammals can effectively distinguish these odorants using the dimensionally-reduced representation provided by olfactory receptor neurons. To account for this capability, normative compressed sensing models have been proposed by previous studies. However, these models do not map cleanly onto the unique anatomy and physiology of the olfactory bulb, nor have they d