Topic: olfactory bulbectomy

The main objective of the study was to investigate the antidepressant like effect of curcumin in olfactory bulbectomized model of depression of male wistar albino rats through behavior screening tests. Bilateral olfactory bulbectomy was performed with rats anesthetized under ketamine (50 mg/kg/i.p.).Twenty male albino wistar rats, weighing 150–220 gm were randomly allocated into four groups (n=5)- Group A (control), Group B(olfactory bulbectomy;OB), Group C {vehicle (0.9% NS, 10 ml/kg) +olfactory bulbectomy,OB} & Group D {curcumin (40 mg/kg)+ olfactory bulbectomy;OB}.Behaviour screening te

Major depressive disorder (MDD) is a global health concern, displaying a diverse range of symptoms and a recognized association with chronic pain. Current evidence suggests that astrocytes play a key role in both disorders. Consequently, we investigated the effect of olfactory bulbectomy (OBX), a well-known model of depression-related behavior, on nociceptive behaviors and the number and morphology of astrocytes within the basolateral amygdala (BLA) in male rats. We conducted behavioral test, including the von Frey assessment of mechanical allodynia and acetone test of thermal cold allodynia,