Topic: olfactory epithelium

Successful recovery after nervous system injury requires not only the restoration of damaged projections, but also appropriate processing of restored input by downstream circuits. How do target circuits adapt to such conditions of denervation and re-innervation? Might they undergo adaptive plastic modifications that promote functional repair and recovery? We addressed these questions by studying a unique model of naturally occurring regeneration in the adult mammalian brain. After a single dose of the olfactotoxin methimazole, olfactory sensory neurons in the nasal olfactory epithelium degener

Clinical data strongly support olfactory impairment as an early indicator of neurodegenerative diseases (ND), including Alzheimer’s disease. In AD patients, neurofibrillary tangles (NFTs) have been identified in the entorhinal cortex and olfactory bulbs, both crucial in olfactory information processing. We therefore investigated the hypothesis that typical ND lesions could appear early in olfactory system regions.We used a tauopathy mouse model (PS19 mice) expressing the human tau protein (1N4R) carrying the P301S mutation. PS19 mice develop NFTs-like inclusions at six months, leading to progr