Topic: olfactory nerve

Olfactory ensheathing cells (OECs) transplantation is emerging as promising nerve repair therapy, particularly for spinal cord injury (SCI), owing to their intrinsic regenerative capacity within the olfactory system. Perineural fibroblasts are natural partners of OECs within the olfactory nerve and co-transplantation with OECs may improve transplantation repair outcomes. However, little is known about the natural interactions of OECs and fibroblasts during the chaotic state following an injury. Using a mouse model, we temporarily damaged the olfactory nerves using methimazole. At key stages of

Sensory systems deploy diverse strategies for discriminating similar stimuli. For instance, spatially isotropic lateral inhibition between neurons showing overlapping receptive fields allows contrast enhancement of primary stimulus representations in the visual system. In the olfactory bulb (OB), odorant identity is primarily represented as a spatially discontinuous map of activated glomeruli. Prior observations on mixture inhibition across glomeruli led us to hypothesize that so-called superficial short-axon-cells -a sub-population of GABAergic/dopaminergic juxtaglomerular cells- underlie a t