Topic: OLIG2

Recent studies show that horizontal L2/3 axonal projections exhibit increased myelin segments elongation following monocular deprivation. Such adaptive myelin plasticity may improve synaptic efficacy of corticocortical connections with a possible role in mediating the reorganization of cortical maps after sensory deprivation. Here, we explored the relationship between axonal myelination and the level of cortical reorganization in distinct layers of the somatosensory cortex following central sensory deprivation. Complete thoracic spinal cord was used to induce sensory deprivation of the cortica

In the central nervous system (CNS), the formation of functional neuronal networks during development depends on the ability of neuroepithelial progenitor (NEPs) to generate neurons and glial cells – oligodendrocytes and astrocytes - in a highly specific manner, both temporally and spatially. In the ventral neural tube, depending on both its concentration and timing of exposure, Sonic Hedgehog (Shh) - released by the notochord and floor plate cells - regulates expression of transcription factors that demarcate distinct NEP domains dedicated to sequentially generate specific neuronal and glial