Topic: oligodendrocyte lineage

The Allan-Herndon-Dudley syndrome (AHDS) is an X-linked human disorder characterized by mutations in the MCT8 gene, critical for thyroid hormone (TH) transport across the blood-brain-barrier (BBB). Such central TH deprivation leads to intellectual disability and movement disorders.To understand disrupted processes and to refine future treatment strategies with TH analogs, we conduced single nucleus RNA sequencing studies in a mouse model engineered to replicate the central TH deficiency of AHDS, featuring a dual deletion of MCT8 and the mouse-specific T4 transporter OATP1C1. Bioinformatical an

Erythropoietin (EPO), a potent growth factor, named after its role in erythropoiesis, has been shown to not only be produced in the brain, but also to have significant effects in improving cognitive performance. The mechanisms by which EPO acts are yet to be fully explored, including the transcriptome changes elicited by it in the oligodendrocyte lineage. Here we explore these changes after a 3-week EPO/Placebo treatment using single-nuclei RNA sequencing. A total of 12.043 nuclei were classified into 5 cell types (oligodendrocyte precursor cell – OPC, committed oligodendrocyte precursor – COP

Painful diabetic neuropathy (pDN) is a serious, chronic complication affecting about 10-20% of diabetes mellitus (DM) patients, but the underlying cause remains unknown. Hints from risk factor assessment and literature point towards a role of oligodendrocyte and myelin homeostasis. Along this line, the main aim of the project is to identify adaptations occurring in the oligodendrocyte lineage due to the metabolic imbalances triggered by DM and determine which of these adaptations are crucial for the development of neuropathic pain. The high-fat high-sugar diet-induced type 2 DM mouse model is