Topic: μ-opioid receptor

Obesity is a multifactorial disease, where the major factor involved is the consumption of high-fat, high-palatability food. The prevalence of this disease has increased in all age groups, but the increase in children and youth is alarming. Food intake is controlled by brain areas involved in homeostatic and hedonic control, both systems being regulated by the GABAergic nucleus, lateral septum (LS). The LS neurons are regulated by several membrane receptors, where the regulation of food intake in an obese condition by μ-opioid receptor (MOR) has not been previously studied.This work aimed to e

Basal ganglia (BG) are believed to involve in motor planning and control. Its striatum receives cortical, thalamic, and substantia nigra inputs and shows uneven distribution of μ-opioid receptor (MOR)-rich striosome and poor matrix. Medium spiny striatal neurons (MSN), distinguished into direct and indirect pathway, are present in both the striosome and matrix. Striatum also contains cholinergic and parvalbumin (PV) interneurons. Despite the complexity, BG are usually discussed with its direct and indirect pathways and overlooking the striosome and matrix compartmentation. Here we studied the