Topic: optical coherence tomography

ePoster: 2 ePosters

Can retina serve as a surrogate marker for cardiovascular risk factor-associated differences in the brain?

Nazife Ayyildiz, Karsten Mueller, Samyogita Hardikar, Frauke Beyer, Cornelia Enzenbach, Ronny Baber, Kerstin Wirkner, Silke Zachariae, Johanna Girbardt, Jordan Hassett, Alfred Anwander, Tobias Elze, Mengyu Wang, A. Veronica Witte, Franziska G. Rauscher, Arno Villringer · FENS Forum 2024

Cardiovascular risk (CVR) factors affect both the retina and the brain. This study investigated whether circumpapillary retinal nerve fiber layer thickness (cpRNFLT) might serve as a surrogate marker of CVR-associated gray-matter density (GMD) and white-matter microstructure (WMM) differences in the brain. We cross-sectionally evaluated retinal Optical Coherence Tomography and brain T1- and Diffusion-weighted Magnetic Resonance Imaging data of the same participant in population-based LIFE-Adult study (Leipzig, Germany). We included 769 participants [44% female, meanAge (SD):54.1(15.8)] in voxe

ePoster · Neuroscience

Retinal dysfunction in Huntington’s disease mouse models is characterized by an early photoreceptor degeneration and a late neuroinflammation

Jorge Navarro Calvo, Paula Martín-Climent, Fátima Cano-Cano, Francisco Martín-Loro, Samanta Ortuño-Miquel, Gema Esquiva, Violeta Gómez-Vicente, Ana I. Arroba, Luis M. Valor · FENS Forum 2024

Huntington’s disease (HD) is a fatal neurodegenerative disorder known for thirty years to be caused by an aberrant expansion of CAG repeats in the HTT gene. Still, no specific biomarkers are routinely applied in the clinical management of patients. The retina is the most accessible area of the CNS system that enables noninvasive monitoring of HD mutation carriers, but we need first to determine how retinal alterations correlate with those of inner brain areas. To this aim, we analyzed the transgenic R6/1 and the knockin zQ175 mouse strains using optical coherence tomography (OCT), gene express

ePoster · Neuroscience