Topic: optogenetic approaches

Parkinson’s disease (PD) is a neurological and neurodegenerative disease characterized by themanifestation of motor and non-motor symptoms. Among these, pain is one of the most frequent,affecting around 85% of patients and contributing to a deterioration in their quality of life.Nowadays, pain treatment in PD is still inefficient due to the lack of knowledge of the underlyingmechanisms. However, we know that pain can be modulated by the monoaminergic descendingpathways projecting to the dorsal horn of the spinal cord (DHSC). Thus, the aim of the present studyis to unravel the involvement of th

Tobacco smoking is a major contributor to the burden of mental health disease worldwide. Nicotine is the primary reinforcing and main addictive component of tobacco. Nicotine addiction is a chronic relapsing disorder associated with multiple psychiatric comorbidities, and few effective interventions currently exist to curb addiction to nicotine. The neurocircuitry underlying nicotine addiction is broad, complex and depends on the stages of the disease process. It is well-acknowledged that nicotine impacts the reward system with prominent alterations of the firing properties of VTA DA neurons c