Topic: orexin-A

The lateral hypothalamus produces the neuropeptides orexin-A and -B, also referred to as hypocretin-1 and -2, which activate the OX1 and OX2 receptors. The orexin system is linked to various neurobiological processes and specifically plays a critical role in regulating the sleep-wake cycle. Epilepsy, as a frequent neurological disease, affects people of all ages. Given that epilepsy can impact sleep in multiple ways, the relationship between the orexinergic system and the pathophysiology of generalized epilepsies remains to be determined.We investigated the orexin-type 2 receptor (OX2R) in the

Complex interactions between serotonin (5-hydroxytriptamine) and orexin (hypocretin) systems in the CNS modulate diverse physiological processes, including mood regulation, energy homeostasis, and spontaneous physical activity. A portion of this interaction may be explained by G protein-coupled receptor oligomerization, which might influence agonist affinity, efficacy, trafficking, and signal transduction. Orexin receptor 1 (OX1) and 5-hydroxytriptamine 2C receptor (5-HT2C) co-express in diverse neuronal populations and are involved in pathological conditions such as anxiety and eating disorde