ePoster · Molecular Neuroscience
Schizophrenia risk gene SP4 I: A call for spatio-temporal expression data on fetal radial glial cells and adult nucleus accumbens
Venkiteswaran Muralidhar · FENS Forum 2024
SP4 gene is one of the two risk genes implicated in schizophrenia in recent large unpublished case-controlled genomic and exomic sequencing studies. Data on Spatio-temporal SP4 expression in the brain and it's biological functions are sparse in published literature. Bulk RNA sequencing and single-cell high-resolution mid-gestation Spatio-temporal RNA sequencing studies on SP4 from certain brain regions were collated and analysed from published and unpublished databases. The results of bulk RNA sequencing show that SP4 is mainly expressed in the fetal brain. Single-cell RNA sequencing of the mi