Orientation-selective responses

…organization and modular network of orientation-selective responses in visual cortex. I show that prior to the onset of structured sensory experience, endogenous mechanisms set up a highly organized cortical network str

Cortical circuits embody remarkably reliable neural representations of sensory stimuli that are critical for perception and action. The fundamental structure of these network representations is thought to arise early in development prior to the onset of sensory experience. However, how these endogenously generated networks respond to the onset of sensory experience, and the extent to which they reorganize with experience remains unclear. Here we examine this ‘nature-nurture transform’ using chronic in vivo calcium imaging to probe the developmental emergence of the representation of orientatio