Topic: Oscilltrack

Neuronal oscillations are a prominent feature of motor cortical local field potentials (LFPs) and abnormalities in oscillatory activity have been linked to several disorders. Theta-modulated gamma-frequency pulses of alternating current stimulation modulate motor learning in humans, however, it is unclear how these frequencies modulate motor cortical activity at the cellular microcircuit level. Here, we aimed to develop a method of bidirectionally modulating theta and gamma coupled oscillations in the motor cortex using closed-loop optogenetic stimulation of excitatory RBP4-Cre (retinol-bindin

Various oscillations are associated with specific aspects of brain function. Oscillations arise from coordinated neuronal activity in reciprocally connected and looping brain networks. Closed-loop brain stimulation precisely aligned to the structure of ongoing activity can be a powerful tool for understanding brain function and providing interventions to ameliorate pathological activity. OscillTrack is a computationally lightweight approach to track primarily the phase and also the amplitude of a waxing and waning oscillation within a frequency band of interest. OscillTrack directly operates o

Deep brain stimulation (DBS) of the fornix is currently being trialled in the treatment of memory impairment, including in Alzheimer’s disease. Commonly, DBS is delivered continuously at 130Hz, but the effect on memory performance of such stimulation has been mixed. Clinicians have suggested that delivering stimulation timed to ongoing neural activity may enhance the efficacy of DBS. Theta oscillations in the hippocampus, which have been hypothesised to support learning and memory, may provide a read out of memory relevant neural activity. Supporting this, optogenetic stimulation of the hippoc