Topic: ovariectomy

Estrogens regulate a variety of processes in the central nervous system (CNS), including inflammatory responses. Therefore, postmenopause, a hypoestrogenic state, may contribute to an increased risk of developing neuroinflammatory-related disorders. Thus, it is proposed to introduce lifestyle changes that could have beneficial effects on the CNS. Regular, moderate physical activity is being considered as a potential intervention for preventing disruption of the neuroinflammation process. The aim was to investigate the impact of voluntary wheel running on neuroinflammation, including Nlrp3 infl

Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting adverse reactions in chemotherapy with cytotoxic anticancer agents. We have demonstrated that CIPN caused by paclitaxel involves high mobility group box 1 (HMGB1), a nuclear protein, derived from macrophages (Mφ) in laboratory animals (Neuropharmacology 141, 201, 2018), and that postmenopausal estrogen decline aggravates CIPN in patients undergoing paclitaxel-based chemotherapy (J Pharmacol Sci 146, 49, 2021). In this study, we analyzed estrogen modulation of upstream and downstream mechanisms of HMGB1. Female mice were subje

According to the literature low body temperature is considered a risk factor for Alzheimer’s disorder (AD) and may contribute to a significant worsening of its histological pathology. Less is known about the alteration of the thermoregulation in AD subjects. Therefore, our aim was to identify it in the popular triple transgenic mouse model (3xTg-AD) of AD.In addition to continuous telemetric monitoring of circadian temperature changes, we used cold and warm stimulations as well as an NK3 agonist (senktide)-induced drop in core body temperature modelling post-menopausal heat waves. Six-month-ol