Oxygen consumption

Energy metabolism in the brain accounts for approximately 20% of the body’s oxygen consumption being glutamatergic transmission a major contributor. To meet these energetic requirements there is a tight coupling between neurons and astrocytes. Thus, neuronal glutamatergic activity decreases astrocytic oxidative glucose metabolism in favor of glucose metabolism to lactate. Lactate released by astrocytes can be oxidatively metabolized by neurons. However, little is known about the interplay between neuronal activity and astrocytic metabolism concerning other energetic sources. Here, we made use

Aims. Acute consumption of sweeteners has become increasingly common in modern diets. However, emerging research suggests that the impact of sweeteners on the hypothalamus, involved in regulating food intake [CA1] and metabolism, may be deleterious. Several studies have raised concerns about their potential effects on brain cellular metabolism (Kohno D et al.,2016), suggesting a mismatch between detection of false sugar and the energy value actually detected. This study aimed to investigate the dose-dependent impact of sweeteners on these energetic processes. Methods. Using the hypothalamic ce

…brain over seconds to hours, making oxygen consumption and glucose uptake widely used proxies of neural activity. However, whether changes in neural activity are causally related to changes in metabolic flux in intact circuits on the sub-second timescales associated with behavior, is unclear. Moreover, it is unclear whether differences between rest and action are associated