Topic: p-CREB

Dopamine D3 receptors (D3Rs) regulate several brain functions such as reward and social behavior by modulating neuronal activity in different brain regions. Although mostly expressed in dopaminergic areas, D3Rs are also present in the hippocampus. Previous results obtained in our laboratory suggested that D3 pharmacological blockade or genetic deletion in D3-knock-out (KO) mice enhanced hippocampal long-term potentiation (LTP) and memory. Based on these findings, here, we aimed to explore the molecular bases underlying this pro-cognitive effect.To determine whether D3R blockade acted via pre-

Morphine is one of the most effective analgesics used in the clinical management of pain. However, prolonged exposure to morphine results in a broad spectrum of adverse effects, including tolerance and addiction. Our prior findings indicate that the activation of the dopamine D4 receptor (D4R) prevents morphine addiction by modulating dopamine signalling in striatal regions involved in drug-habit formation and consolidation, without altering morphine-induced analgesia. Furthermore, it has been demonstrated that D4R in the terminals of primary nociceptors contributes to the anti-nociceptive eff