Topic: P2Y1 receptor

The neurodegenerative process in Parkinson’s disease involves exacerbated inflammation with the participation of astrocytes. The P2Y1 receptor (P2Y1R) is a purinergic receptor predominantly expressed in astrocytes, regulating their activity, proliferation, and glutamate release. Therefore, our investigation explores whether the P2Y1R contributes to dopaminergic neuron degeneration, potentially via astrocytic involvement. To study dopaminergic degeneration, we injected 9 µg 6-hydroxydopamine into the right striatum (STR) of male Sprague-Dawley rats aged 6-8 weeks (ethical approval: 167/2019). D

The medial prefrontal cortex (mPFC) is a cortical brain region characterized by complex cognitive functions, such as working memory and decision making. These complex functions are based on a finely tuned interaction between excitatory pyramidal neurons, inhibitory GABAergic interneurons and astrocytes. Astrocytes as well as neurons express a variety of neurotransmitter receptors, the activation of which leads to an increase in intracellular calcium (Ca2+). The aim of this study was to characterize the purinergic Ca2+ signaling and to identify the involved receptors in astrocytes of the mPFC.C