Topic: P300

Cognitive-motor (C-M) interference is a phenomenon during which demands from concurrent cognitive and motor tasks create competition for available neural resources. Research introduces this competition using dual-task designs to compare performance on single-task situations to dual-tasks, which require both motor and cognitive engagement. However, while some individuals experience C-M interference, others have a more integrative effect, presenting as better adaptation to multi-modal demands. Little is known about how this C-M relationship develops, nor what factors play a role in the integrati

Older adults show deficits in tasks of set-shifting. Yet, many underlying cognitive functions are required during such tasks and it is currently unknown which of these mechanisms may be deficient in older age. Here, we investigated this question in a preliminary dataset of 45 young participants (age: 25.2 ± 4.3) and 26 older participants (age: 68.1 ± 5.0) in an EEG-compatible set-shifting paradigm. We were particularly interested in two posterior components: 1) The P300 is a positive component that appears approximately 300 ms to 500 ms after the cue and has a lower amplitude during set-shifti

Imagery of sensations and attention to them are mental operations that have similarities but differ in function. Imagery generates internal sensory representations while attention prioritizes external or internal signals. This distinction is less clear in certain sensory systems such as the somatosensory system. Our study aimed to explore neural activity changes induced by tactile imagery (TI) and tactile attention (TA). Given the established facilitatory effect of TI on somatosensory processing, our study also aimed to investigate the effects of TA on somatosensory processing.Ten participants

Activity-driven transcription is a crucial step in neuronal plasticity processes. We found that during neuronal activation induced by the proepileptic drug kainic acid, there is a dramatic genomic redistribution of the transcriptional cofactors CBP and p300. These cofactors leave their default location at enhancer and promoter regions related with cell identity to occupy regulatory regions at activity-induced genes. In parallel with these changes, we also detect changes in the levels of H3K27ac and chromatin accessibility accordingly with the redistribution and modification of the epigenetic c

Bright lights cause us to wake up, unexpected colors divert our attention and threatening creatures trigger a flight response. These instinctual processes in response to visual cues are robust during wakefulness. However, since the study of visual processes of the sleeping brain has been limited by the closed eyelids, we do not know what neuronal activity these stimuli trigger during sleep. Using sleep compatible virtual reality goggles, we aimed to investigate which visual functions persisted during NREM sleep in humans sleeping with eyes open. Here we designed a series of experiments to elic