Topic: pain thresholds

Activity of the insular cortex had been consistently suggested to be related with chronic pain. Of the sub-regions in the insular cortex, the posterior insular cortex (pIC) receives inputs from brain regions that receive primary sensory inputs. Anatomical changes of the pIC were reported in neuropathic pain conditions. However, how the activity of pIC neurons may be related with neuropathic pain remain to be investigated. We, therefore, investigated the role of pIC pyramidal neurons and neuropathic pain using optogenetics and fiberphotometry using male mice. We found that inhibiting the activi

We explored the potential of altering movement-evoked pain in individuals with chronic low back pain (LBP) by manipulating visual proprioceptive cues through virtual reality (VR). Additionally, we investigated whether individuals with higher levels of pain, kinesiophobia, disability and catastrophizing might demonstrate greater susceptibility to visual feedback manipulation. In this cross-sectional study, 50 patients with non-specific chronic LBP extended their lumbar spine until the onset of pain. This was done both without the use of VR and using the VR. The visual feedback regarding the amo